Inhibitors of the interaction between MDM2 and P53

The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, s, t, R , R , R , R , R , R , R , X, Y, Q and Z have definited definition.

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Bibliographische Detailangaben
Hauptverfasser:	GIETHLEN BRUNO, ARTS JANINE, WERMUTH CAMILLE GEORGES, LIGNY YANNICK AIME EDDY, CONTRERAS JEAN-MARIE, CSOKA IMRE CHRISTIAN FRANCIS, VAN HIJFTE LUC, LACRAMPE JEAN FERNAND ARMAND, JOUBERT MURIEL, MEYER CHRISTOPHE, SCHOENTJES BRUNO
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, s, t, R , R , R , R , R , R , R , X, Y, Q and Z have definited definition.