Glycerol branched polyethylene glycol human growth hormone conjugates, process for their preparation, and methods of use thereof

Glycerol branched polyethylene glycol human growth hormone conjugates, process for their preparation, and methods of use thereof

The present invention relates to PEGylation of human Growth Hormone (hGH) using a glycerol branched PEG. The present invention also relates to processes for the PEGylation of hGH. In addition, the present invention relates to pharmaceutical compositions comprising the PEGylated hGH. A further embodi...

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Bibliographische Detailangaben
1. Verfasser: FINN RORY F.,SIEGEL NED R
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to PEGylation of human Growth Hormone (hGH) using a glycerol branched PEG. The present invention also relates to processes for the PEGylation of hGH. In addition, the present invention relates to pharmaceutical compositions comprising the PEGylated hGH. A further embodiment is the use of the PEGylated hGH for the treatment of growth and development disorders.