Method for producing condensed imidazole compound, reformatsky reagent having stable form and production thereof

A process for industrially advantageously producing a steroid C17,20-lyase inhibitor represented by the following general formula (I); and a Reformatsky reagent in a stable form which is suitable foruse in the production process. Either a specific ss-hydroxy ester compound derivative obtained from a...

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Bibliographische Detailangaben
Hauptverfasser:	HANDA HISAFUMI, MIKI MASATAKA, NAKAMOTO KOJI, KAWAKAMI JUNICHI, NUWA UTSU
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A process for industrially advantageously producing a steroid C17,20-lyase inhibitor represented by the following general formula (I); and a Reformatsky reagent in a stable form which is suitable foruse in the production process. Either a specific ss-hydroxy ester compound derivative obtained from a specific carbonyl compound by the Reformatsky reaction or a salt of the compound is reduced in thepresence of a metal/hydrogen complex compound and a metal halide and then subjected to ring closure to thereby obtain a compound represented by the general formula (I): (I) wherein the symbols have the same meanings as defined in the description. In the Reformatsky reaction, a stable solution of the compound represented by BrZnCH2COOC2H5 or crystals of the compound represented by (BrZnCH2COOC2H5.THF)2 are useful.