Substituted pyridine derivatives as sarm1 inhibitors

Esta divulgación se refiere a los derivados de la piridina, las composiciones de los mismos, y métodos asociados, útiles para la inhibición de la actividad de SARM1 y/o para el tratamiento o prevención de trastornos neurológicos. This disclosure is drawn to pyridine derivatives, compositions thereof: and associated methods, useful for inhibition of SARM1 activity and/or for treating or preventing neurological disorders. SARM1 activation can cause a rapid reduction in NAD+ levels in injured axons, which then undergo degeneration. In particular embodiments, the compounds inhibit axonal degeneration, including axonal degeneration that results from reduction or depletion of NAD+ (e.g., inhibition of SARM1 NADase). This disclosure is drawn to pyridine derivatives, compositions thereof, and associated methods, useful for inhibition of SARM1 activity and/or for treating or preventing neurological disorders.