Exatecan derivatives and antibody-drug conjugates thereof

En este documento se describen, en parte, nuevos derivados de exatecán con nuevos enlazadores químicos que incluyen unidades escindibles de catepsina B y se conjugan con anticuerpos objetivo. Disclosed herein, in part, are compounds (I) which are exatecan derivatives with novel chemical linkers that include cathepsin B cleavable moieties, and conjugated to targeting antibodies. Disclosed herein, in part, are compounds (I) which are exatecan derivatives with novel chemical linkers that include cathepsin B cleavable moieties, and conjugated to targeting antibodies.