Methods of treatment with myosin modulator

En la presente se describen métodos de tratamiento que comprenden administrar una cantidad terapéuticamente eficaz de un modulador de la miosina o una sal farmacéuticamente aceptable de este a un sujeto que lo necesite y métodos de diagnóstico útiles en relación con esos tratamientos. Debido a observaciones desarrolladas en ensayos clínicos con mavacamten y con mavacamten y otros inhibidores de la miosina en el ámbito preclínico, en la presente se proporcionan nuevos conocimientos sobre cómo pueden usarse los inhibidores de la miosina de manera beneficiosa para influir en el grado de actividad de la HCM y otras enfermedades. Disclosed herein are methods of treatment comprising administering a therapeutically effective amount of a myosin modulator or a pharmaceutically acceptable salt thereof to a subject in need thereof and diagnostic methods useful in connection with those treatments. Due to observations unfolding in clinical trials with mavacamten and with mavacamten and other myosin inhibitors in the pre-clinical setting, new insights into how myosin inhibitors can be used beneficially to impact the disease state of HCM and other diseases are provided herein. Disclosed herein are methods of treatment comprising administering a therapeutically effective amount of a myosin modulator or a pharmaceutically acceptable salt thereof to a subject in need thereof and diagnostic methods useful in connection with those treatments. Due to observations unfolding in clinical trials with mavacamten and with mavacamten and other myosin inhibitors in the pre-clinical setting, new insights into how myosin inhibitors can be used beneficially to impact the disease state of HCM and other diseases are provided herein.