Vacuna recombinante contra enteropatía proliferativa en animales

Vacuna recombinante contra Lawsonia intracellularis basada en una variante quimerica sintética recombinante de proteínas de membrana e invasinas de dicha bacteria, Adicionalmente, se divulgan secuencias nucleotidicas sintéticas que codifican dichas variantes proteicas, proteínas recombinantes como tales, un casete de expresión de dichos antigenos sintéticos proteicos, una célula transformada y un método para Ia producción de dichos antigenos, demostrando su antigenicidad y potencial de protección al patógeno Lawsonia intracellularis. The present invention relates to a recombinant vaccine against Lawsonia intracellularis, based on a recombinant synthetic chimeric variant of membrane proteins and invasins of said bacteria. In addition, the invention discloses synthetic nucleotide sequences encoding said protein variants, recombinant proteins as such, an expression cassette of said synthetic protein antigens, a transformed cell, and a method for producing said antigens, demonstrating the antigenicity and protective potential thereof against the pathogen Lawsonia intracellularis.