Heteroarilos inhibidores de syk

COMPUESTOS DERIVADOS DE HETEROARILOS, INHIBIDORES DE SYK; FORMULACIONES FARMACEUTICAS; COMPUESTOS INTERMEDIARIOS; Y USO PARA EL TRATAMIENTO DE UNA ENFERMEDAD SELECCIONADA DEL GRUPO QUE CONSISTE EN RINITIS ALERGICA, DERMATITIS ALERGICA, LUPUS ERITEMATOSO, NEFRITIS LUPICA, ARTRITIS REUMATOIDE, ASMA, E...

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Hauptverfasser: KLICIC JASNA, HOFFMANN MATTHIAS, WALKER EDWARD, MACCARTHY CLIVE, NAPIER SPENCER, SCOTT JOHN, PARRISH KAREN, SWANTEK FITZGERALD JENNIFER L, DAHMANN GEORG, LAMB DAVID JAMES
Format: Patent
Sprache:spa
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Zusammenfassung:COMPUESTOS DERIVADOS DE HETEROARILOS, INHIBIDORES DE SYK; FORMULACIONES FARMACEUTICAS; COMPUESTOS INTERMEDIARIOS; Y USO PARA EL TRATAMIENTO DE UNA ENFERMEDAD SELECCIONADA DEL GRUPO QUE CONSISTE EN RINITIS ALERGICA, DERMATITIS ALERGICA, LUPUS ERITEMATOSO, NEFRITIS LUPICA, ARTRITIS REUMATOIDE, ASMA, EPOC Y HEPATITIS, ENTRE OTRAS. The invention relates to new substituted heteroaryls of formula (1), wherein A is selected from the group consisting of N and CH, D is CH, E is selected from the group consisting of C and N, T is C, G is selected from the group consisting of C and N, and wherein each of the broken (dotted) double bonds in ring 1 are selected from either a single bond or a double bond under the proviso that all single and double bonds of ring 1 are arranged in such a way that they all form together with ring 2 an aromatic ring system, and wherein R1, M and R3 are defined according to claim 1, and to the above compounds for the treatment of a disease selected from the group consisting of asthma, COPD, allergic rhinitis, allergic dermatitis, lupus erythematodes, lupus nephritis and rheumatoid arthritis.