Inhibidores de azaquinazoline de proteína atípica kinase c

COMPUESTOS DERIVADOS DE pirido[3,4-d]pirimidina; COMPOSICION FARMACEUTICA QUE LOS COMPRENDE Y EL USO PARA TRATAR UN TRASTORNO O CONDICION DEPENDIENTE DE APKC TAL COMO UN TRASTORNO PROLIFERATIVO. The present application provides azaquinazoline compounds as defined herein. This application further des...

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Hauptverfasser:	GREGORY R. OTT, ALLISON L. ZULLI, KATHERINE M. FOWLER, EUGEN F. MESAROS, CRAIG A. ZIFICSAK, IKEOLUWA OLOWAYE, ROBERT L. HUDKINS, NATHANIEL JT MONCK, CHRISTELLE N. SOUDY, HENRY J. BRESLIN, BRUCE D. DORSEY, JONATHAN R.A. ROFFEY, MING TAO, EMMA L. MORRIS, BENJAMIN J. DUGAN, GREGOIRE A PAVE
Format:	Patent
Sprache:	spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	COMPUESTOS DERIVADOS DE pirido[3,4-d]pirimidina; COMPOSICION FARMACEUTICA QUE LOS COMPRENDE Y EL USO PARA TRATAR UN TRASTORNO O CONDICION DEPENDIENTE DE APKC TAL COMO UN TRASTORNO PROLIFERATIVO. The present application provides azaquinazoline compounds as defined herein. This application further describes compositions comprising the same. These azaquinazoline compounds and their salts have atypical protein kinase C ("aPKC") inhibitory activity, and may be used to treat proliferative disorders.