Compuestos derivados de benzodioxano con actividad inhibidora de leucotrieno a4 hidrolasa(lat4h), composicion farmaceutica que los comprende, uso para preparar un medicamento para el tratamiento de enfermedades cardiovasculares tales como ateroesclerosis, infarto de miocardio, apoplejia, aneurisma de aorta, hipertension pulmonar arterial, entre otras

The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositi...

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Hauptverfasser: KIRRANE, THOMAS MARTIN, JR, ZHANG, QIANG, BURKE, MICHAEL J, ZHANG, QING, NETHERTON, MATTHEW RUSSELL, ABEYWARDANE, ASITHA, SMITH KEENAN, NANA LOUISE, PADYANA, ANIL KUMAR, TURNER, MICHAEL ROBERT, TAKAHASHI, HIDENORI
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Sprache:spa
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Zusammenfassung:The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.