Polipeptido que comprende un dominio decimo de fibronectina de tipo iii que se unen a la proteina covertasa subtilisina kexina tipo q ( pcsk9); composicion farmacéutica que comprende dicho polipeptido

Polipéptido que comprende un dominio décimo de fibronectina de tipo III que se unen a la proteína covertasa subtilisina kexina tipo Q (PCSK9); composición farmacéutica que comprende dicho polipéptido. The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The in...

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Hauptverfasser:	RAKESTRAW GINGER C, SITKOFF DOREE F, MITCHELL TRACEY S, PARKER REX A, CAMPHAUSEN RAY, LIPOVSEK DASA, LO CHING-HSIUNG FREDERICK, SAEED KOTHE AMNA, CLOAD SHARON T, DENHEZ FABIENNE M, LOW CHEE MENG, RUSSO KATIE A, DAVIS JONATHAN H, MIAO BOWMAN
Format:	Patent
Sprache:	spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Polipéptido que comprende un dominio décimo de fibronectina de tipo III que se unen a la proteína covertasa subtilisina kexina tipo Q (PCSK9); composición farmacéutica que comprende dicho polipéptido. The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.