COMPUESTOS DERIVADOS DE 1-CARBOXI-2-AMIDA PIRROLIDINA; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHOS COMPUESTOS; Y SU USO PARA TRATAR FIBROSIS QUISTICA, CARCINOMA PULMONAR, BRONQUITIS CRONICA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, ASMA O UNA INF

COMPUESTOS DERIVADOS DE 1-CARBOXI-2-AMIDA PIRROLIDINA; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHOS COMPUESTOS; Y SU USO PARA TRATAR FIBROSIS QUISTICA, CARCINOMA PULMONAR, BRONQUITIS CRONICA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, ASMA O UNA INF

The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prosta...

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Bibliographische Detailangaben
Hauptverfasser: TULLY, DAVID C., CHATTERJEE, ARNAB K., VIDAL, AGNES, BURSULAYA, BADRY Y SPRAGGON, GLEN
Format: Patent
Sprache:spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 ( e.g ., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.