COMPUESTOS DERIVADOS DE HETEROCICLOS SUSTITUIDOS CON MORFOLINA, INHIBIDORES DE LA ACTIVIDAD DE PI3 QUINASA; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHOS COMPUESTOS; KIT FARMACEUTICO; Y SU USO EN EL TRATAMIENTO PROFILACTICO O TERAPEUTICO DEL CANCER

COMPUESTOS DERIVADOS DE HETEROCICLOS SUSTITUIDOS CON MORFOLINA, INHIBIDORES DE LA ACTIVIDAD DE PI3 QUINASA; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHOS COMPUESTOS; KIT FARMACEUTICO; Y SU USO EN EL TRATAMIENTO PROFILACTICO O TERAPEUTICO DEL CANCER

Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases in...

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Bibliographische Detailangaben
1. Verfasser: CASTANEDO GEORGETTE,DOTSON JENNAFER,GOLDSMITH RICHARD,GUNZNER JANET,HEFFRON TIM,MATHIEU SIMON,OLIVERO ALAN,SUTHERLIN DAN
Format: Patent
Sprache:spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.