COMPUESTOS DERIVADOS DE ESPIRO-OXINDOL; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHO COMPUESTO; Y USO DEL COMPUESTO EN EL TRATAMIENTO DEL DOLOR, CANCER, PRURITO, HIPERPLASIA PROSTATICA BENIGNA, HIPERCOLESTEROLEMIA

COMPUESTOS DERIVADOS DE ESPIRO-OXINDOL; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHO COMPUESTO; Y USO DEL COMPUESTO EN EL TRATAMIENTO DEL DOLOR, CANCER, PRURITO, HIPERPLASIA PROSTATICA BENIGNA, HIPERCOLESTEROLEMIA

This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein j, k, m, Q, X, R1, R2a, R2b, R2c, R2d and R3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, N-oxide, solvate or prodrug...

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Hauptverfasser: CADIEUX, JEAN-JACQUES, CHOWDHURY, SULTAN, FU, JIANMIN, HSIEH, TOM, JIA, QI, KAMBOJ, RAJENDER, LIU, SHIFENG, SUN, JIANYU
Format: Patent
Sprache:spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein j, k, m, Q, X, R1, R2a, R2b, R2c, R2d and R3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, N-oxide, solvate or prodrug thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.