COMPUESTOS DERIVADOS DE AZABENZOTIOFENIL; COMPOSICION FARMACEUTICA; Y USO PARA LA INHIBICION DEL CRECIMIENTO CELULAR ANOMALO O DE TRATAMIENTO DE UN TRASTORNO HIPERPROLIFERATIVO

The invention relates to azabenzothiophenyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzothiophenyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or...

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Bibliographische Detailangaben
Hauptverfasser:	PRICE, STEPHEN, WILLIAMS, KAREN, SAVY, PASCAL PIERRE, DYKE, HAZEL JOAN, MONTANA, JOHN GARY, STANLEY, MARK S., BAO, LIANG
Format:	Patent
Sprache:	spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to azabenzothiophenyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzothiophenyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.