PROCEDIMIENTO DE PREPARACION DE CLORHIDRATO DE QUINAPRIL POR REACCION ENTRE UNA 2,5-DIOXO-OXAZOLIDINA Y UN ESTER TERBUTILICO DE UNA TETRAHIDRO ISOQUINOLINA, UTIL COMO PRINCIPIO ACTIVO PARA TRATAR LA HIPERTENSION Y LA INSUFICIENCIA CARDIACA CONGESTIVA

PROCEDIMIENTO DE PREPARACION DE CLORHIDRATO DE QUINAPRIL POR REACCION ENTRE UNA 2,5-DIOXO-OXAZOLIDINA Y UN ESTER TERBUTILICO DE UNA TETRAHIDRO ISOQUINOLINA, UTIL COMO PRINCIPIO ACTIVO PARA TRATAR LA HIPERTENSION Y LA INSUFICIENCIA CARDIACA CONGESTIVA

Methods and materials for preparing quinapril, its pharmaceutically acceptable salts, including quinapril hydrochloride, are disclosed. The method includes reacting (2S,4S)-2-(4-methyl-2,5-dioxo-oxazolidin-3-yl)-4-phenyl-butyric acid ethyl ester with (3S)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic...

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Bibliographische Detailangaben
1. Verfasser: SANDRA MARIE JENNINGS
Format: Patent
Sprache:spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Methods and materials for preparing quinapril, its pharmaceutically acceptable salts, including quinapril hydrochloride, are disclosed. The method includes reacting (2S,4S)-2-(4-methyl-2,5-dioxo-oxazolidin-3-yl)-4-phenyl-butyric acid ethyl ester with (3S)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid tert-butyl ester to yield quinapril tert-butyl ester, which is subsequently reacted with an acid to yield quinapril or an acid addition salt of quinapril.