CH669787
Compounds of the formula (I> wherein X represents a bond, C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene and Y represents a bond, C1-4 alkylene, C2-4 alkenylene or C2-4 alkynylene, the sum total of carbon atoms in X and Y being not more than 8; Ar represents a phenyl group substituted by one o...
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Zusammenfassung: | Compounds of the formula (I> wherein X represents a bond, C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene and Y represents a bond, C1-4 alkylene, C2-4 alkenylene or C2-4 alkynylene, the sum total of carbon atoms in X and Y being not more than 8; Ar represents a phenyl group substituted by one or more substituents selected from nitro, -(CH2)qR [where R is C1-3 alkoxy, -NR R (where R and R each represent a hydrogen atom, or a C1-4 alkyl group, or-NR R forms a saturated heterocyclic amino group which has 5-7 ring members), -NR COR (where R represents a hydrogen atom or a C1-4alkyl group, and R represents a hydrogen atom or a C1-4alkyl, C1-4alkoxy or-NR R group), and q is 1 to 3], -(CH2)rR [where R represents -NR SO2R (where R represents a C1-4 alkyl, phenyl or -NR R group),- NR COCH2N(R )2 (where each of the groups R represents a hydrogen atom or a C1-4 alkyl group), -COR (where R represents hydroxy, C1-4 alkoxy or a NR R ), -SR (where R is a hydrogen atom, or a C1-4 alkyl group optionally substituted by hydroxy, C1-4 alkoxy or NR R ), -SOR , -SO2R10, -CN, or -NR11R (where R and R represent a hydrogen atom or a C1-4 alkyl group, at least one of which is C2-4 alkyl substituted by a hydroxy, C1-4 alkoxy or NR R group), and r is 0 to 3], -O(CH2)qCOR , or -O(CH2)tR [where R represents hydroxy, NR R , NR R or a C1-4alkoxy group optionally substituted by hydroxy, C1-4 alkoxy or NR R ,and t is 2 or 3]. R and R each represents a hydrogen atom or a C1-3 alkyl group, the sum total of carbon atoms in R and R being not more than 4; and physiologically acceptable salts and solvates (e.g. hydrates) thereof, have a stimulant action at a beta 2-adreno-receptors and may be used in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis. |
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