3-(2-aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]h ept-2-ene-2-carboxylic acid

3-(2-aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]h ept-2-ene-2-carboxylic acid

The compounds of the formula I with the absolute configurations 5S, 6S, 8R; 5R, 6R, 8R; 5S, 6S, 8S; 5S, 6R, 8R and 5S, 6R, 8S; their pharmacologically acceptable salts, and mixtures of two or more isomers with the absolute configuration 5R, 6R, 8S; 5S, 6S, 8R; 5R, 6R, 8R; 5S, 6S, 8S; 5R, 6S, 8S; 5S,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: SUSAN MARGARET SCHMITT, BURTON GRANT CHRISTENSEN, DAVID BRUCE RANDOLPH JOHNSTON
Format: Patent
Sprache:eng ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The compounds of the formula I with the absolute configurations 5S, 6S, 8R; 5R, 6R, 8R; 5S, 6S, 8S; 5S, 6R, 8R and 5S, 6R, 8S; their pharmacologically acceptable salts, and mixtures of two or more isomers with the absolute configuration 5R, 6R, 8S; 5S, 6S, 8R; 5R, 6R, 8R; 5S, 6S, 8S; 5R, 6S, 8S; 5S, 6R, 8R; 5R, 6S, 8R and 5S, 6R, 8S are described. The compounds are prepared by multi-step total syntheses. They are employed as active compounds in antibiotic medicaments and have activity against pathogenic microorganisms such as Gram-positive and Gram-negative bacteria.