Therapeutically active 6-(alpha-hydroxyethyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives, and processes for their preparation

Therapeutically active 6-(alpha-hydroxyethyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives, and processes for their preparation

The therapeutically active compounds of the formula III, in which the dotted line indicates the unsaturated or saturated 2,3 bond and R' and X have the meaning given in Claim 1, as well as their pharmaceutically acceptable salts and esters, are valuable antibiotics. They can be obtained by hydr...

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Bibliographische Detailangaben
Hauptverfasser: DAVID HOUNG-MIN SHIH, BURTON GRANT CHRISTENSEN
Format: Patent
Sprache:eng ; ger
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The therapeutically active compounds of the formula III, in which the dotted line indicates the unsaturated or saturated 2,3 bond and R' and X have the meaning given in Claim 1, as well as their pharmaceutically acceptable salts and esters, are valuable antibiotics. They can be obtained by hydrogenating cleavage and, where appropriate, by hydrogenating the double bond of thienamycin of the formula IV and its derivatives.