VERFAHREN ZUR HERSTELLUNG VON NEUEN 13-THIAPROSTANSAEUREDERIVATEN

13-Thiaprostanoic acid derivatives of the general formula I (I) wherein A is -CO- or -CHOH-; B is -CH2CH2- or -CH=CH-; Q is 1,4-phenylene or 1,4-naphthylene; R1 is H or OH; R2 is H or CH3; R3 is alkyl with 1-8 carbon atoms or alkyl with 1-8 carbon atoms substituted by (a) phenyl, (b) phenyl substitu...

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Bibliographische Detailangaben
Hauptverfasser:	MANFRED BAUMGARTH, HANS-JOACHIM ENENKEL, HANS-ECKART RADUNZ, HANS-JOCHEN SCHLIEP, DIETER ORTH
Format:	Patent
Sprache:	ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	13-Thiaprostanoic acid derivatives of the general formula I (I) wherein A is -CO- or -CHOH-; B is -CH2CH2- or -CH=CH-; Q is 1,4-phenylene or 1,4-naphthylene; R1 is H or OH; R2 is H or CH3; R3 is alkyl with 1-8 carbon atoms or alkyl with 1-8 carbon atoms substituted by (a) phenyl, (b) phenyl substituted by at least one of CH3, F, Cl, Br, OH, OCH3 or CF3; (c) phenoxy or (d) phenoxy substituted by at least one of CH3, F, Cl, Br, OH, OCH3 or CF3; and R4 is NH2, CH3, phenyl, p-acetylaminophenyl, p-benzoylaminophenyl or phenylamino. These compounds are useful for lowering blood pressure as well as for other pharmaceutical purposes. They also are useful intermediates for the preparation of other known pharmaceuticals such s the 13-thiaprostaglandins.