CH608812

CH608812

Deoxystreptamine derivs. of formula (I) and their acid addn. salts are new: In the formula, R1 = H or 1-4C alkyl. R2 = NH2 or OH. One of R3 and R4 = H, the other is glycosyl. n = 4, 5 or 6. Cpds.(I) are prepd. e.g. by reducing corresp. amides having -NH.CO.CH(OH) in place of NHCH2CH(OH).(I) are anti...

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Bibliographische Detailangaben
1. Verfasser: JAMES WILLIAM MOORE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Zusammenfassung:Deoxystreptamine derivs. of formula (I) and their acid addn. salts are new: In the formula, R1 = H or 1-4C alkyl. R2 = NH2 or OH. One of R3 and R4 = H, the other is glycosyl. n = 4, 5 or 6. Cpds.(I) are prepd. e.g. by reducing corresp. amides having -NH.CO.CH(OH) in place of NHCH2CH(OH).(I) are antibacterials useful for treating Gram positive or negative infections in humans and animals. The usual human dose is 0.1-50mg/kg/day parenterally or 10-100mg/kg/day orally. The specifically claimed cpd. 1-N-(5)-2-hydroxy-6-aminohexyl-kanamycin A is prepd. by reducing 1-N-(5)-2-hydroxy-6-aminohexanoylkanamycin A with B2H6