Pseudo-indole derivs

Basically substd. pseudo-indoles and their non-toxic acid addn. salts (I) where R1 = Me or Ph R2 = H, halogen atom, Me or MeO R3 = alkyl (C1-C4) or phenyl which may be subst. by halogen atoms or alkyl or alkoxy gps. (C1-C4) R4 = alkenyl (C2-C4) R5 = alkyl substd. by a cycloalkyl gp. (C3-C8), a strai...

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Hauptverfasser: LANDGRAF,KLAUS,DR, SEEGER,ERNST,DR
Format: Patent
Sprache:eng ; ger
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Zusammenfassung:Basically substd. pseudo-indoles and their non-toxic acid addn. salts (I) where R1 = Me or Ph R2 = H, halogen atom, Me or MeO R3 = alkyl (C1-C4) or phenyl which may be subst. by halogen atoms or alkyl or alkoxy gps. (C1-C4) R4 = alkenyl (C2-C4) R5 = alkyl substd. by a cycloalkyl gp. (C3-C8), a straight or branched chain alkenyl gp. or an aralkyl gp., or R4 and R5 together with the N atom to which they are attached may form a satd. or partly satd. heterocyclic ring which may contain an additional O or N atom and which is substd. by a phenyl gp., where the phenyl itself may be subst. by halogen atoms, OH gps. or alkyl or alkoxy gps. (C1-C4). A = a straight or branched chain divalent hydro-carbon gp. (C2-C4). Cpds. I have good analgesic activity and also anti-inflammatory, antitussive and spasmolytic activity. 2-methyl-3-phenyl-3-(2-(4-phenyl-piperidino)-ethyl)-pseudoindole (60 g), b.p. 210-220 deg.C/0.005 mm.Hg.