Hypotensive dihydropyridines

Hypotensive dihydropyridines

(A) Pharmaceutical prepns. contng. as active ingredient a dihydropyridine deriv. (I) R' = 1-6C alkyl R2 = COOR', COR" R3 = Ph opt. substd. by mono/di-halo, mono/di/tri-1-4C alkyl/alkoxy, CF3; benzyl styryl, furyl, thienyl R4 = H, 1-6C alkyl R',R" = 1-6C alkyl (B) Cpds. of fo...

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Bibliographische Detailangaben
Hauptverfasser: EARL TEDESCHI,RALPH, LOEV,BERNARD
Format: Patent
Sprache:eng ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:(A) Pharmaceutical prepns. contng. as active ingredient a dihydropyridine deriv. (I) R' = 1-6C alkyl R2 = COOR', COR" R3 = Ph opt. substd. by mono/di-halo, mono/di/tri-1-4C alkyl/alkoxy, CF3; benzyl styryl, furyl, thienyl R4 = H, 1-6C alkyl R',R" = 1-6C alkyl (B) Cpds. of formula (II):- As hypotensive agents. Unit doses; 25-250 mg. for oral admin. at levels of 0.5-5 mg/kg.