Hydroxycycloalkylamines antipyretics antitussives

Hydroxycycloalkylamines antipyretics antitussives

(A) Cmpds. - (I) Hal = Cl or Br - R' = H, Cl, or Br - R2 = H or Me - (B) Acid addn. salts of (I). - Antipyretics, antitussives, secretolytics, and mucolytics. N-(cis-m-hydroxy-cyclohexyl)-(2-chloro-4-nitrobenzyl)-amine. HCl (11 g.) was hydrogenated in MeOH (150 ml.) and H2O (20 ml.), at 20 deg....

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Bibliographische Detailangaben
Hauptverfasser: KECK,JOHANNES,DR, SCHRAVEN,ECKHARD,DR, BEISENHERZ,GERWIN,DR, KOSS,FRIEDRICH-WILHELM,DR
Format: Patent
Sprache:eng ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:(A) Cmpds. - (I) Hal = Cl or Br - R' = H, Cl, or Br - R2 = H or Me - (B) Acid addn. salts of (I). - Antipyretics, antitussives, secretolytics, and mucolytics. N-(cis-m-hydroxy-cyclohexyl)-(2-chloro-4-nitrobenzyl)-amine. HCl (11 g.) was hydrogenated in MeOH (150 ml.) and H2O (20 ml.), at 20 deg./5 atm. over PtO2 (0.1 g.)., filtered, dild. with Et2O, filtered off and recryst. from MeOH, giving the 4-amine, m.p. 208-9 deg. (dec.).