Verfahren zur Herstellung neuer Naphthyridin-Derivate

Verfahren zur Herstellung neuer Naphthyridin-Derivate

(A) Cmpds. (I) and (III):- R' = lower alkyl R2 = H or Me R3 = lower Oalkyl or together = -OCH2O-IA - X = H; IB - X = double bond. (B) Salts (II) of (I). (I) and (II) Analgesics. Dose 100-500 mg. (III) Intermediates for (I) and (II) Racemic cis-1-methyl-3-(3,4-methylenedioxy-phenyl)-4-piperidyl-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LINDENMANN,ADOLF,DR, SUEESS,RUDOLF,DR
Format: Patent
Sprache:ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:(A) Cmpds. (I) and (III):- R' = lower alkyl R2 = H or Me R3 = lower Oalkyl or together = -OCH2O-IA - X = H; IB - X = double bond. (B) Salts (II) of (I). (I) and (II) Analgesics. Dose 100-500 mg. (III) Intermediates for (I) and (II) Racemic cis-1-methyl-3-(3,4-methylenedioxy-phenyl)-4-piperidyl-amine (6.0 g.), 2 N HCl (35 ml.), and 35% HCHO (5 g.) were stirred 30 mins. at 20 deg., heated 30 mins. at 100 deg., evapd., and recryst. from MeOH, giving the racemic-naphthyridine-HCl, m.p. 304 deg.