Procédé de préparation de composés organiques de l'aluminium

Pharmaceutically active organic aluminium compounds are prepared by reacting one or more aluminium alkoxides with water and at least one pharmacologically active substance containing at least one hydroxy, carboxylic acid, phenolic, imido or keto-enolic group, and with at least one substance containing a hydrolysis-limiting group selected from oleic acid, stearic acid, oleyl alcohol, stearyl alcohol, ceto-stearyl alcohol, castor oil and benzoic acid until a polymeric reaction product is obtained. The alkoxides are preferably derived from alcohols containint 2 to 5 carbon atoms. The amount of water used in the above process may be from 0.5 mol to 1 mol per mol of aluminium alkoxide. Suitable pharmacologically active substances for use in the above process are tribromoethanol, trichloro-t-butanol, 3-methyl-1-pentyn-3-ol, chloral hydrate, benzyl alcohol, 3-(2-methyl-phenoxy)-propane-1, 2-diol, glycerol, ethanolamine, salicylic acid and esters thereof, acetyl salicylic acid, p-amino-salicylic acid, barbituric acid, saccharin, ascorbic acid, gluconic acid, glucose, sorbitol, sucrose, maltose, raffinose, lactose, testosterone, androsterone, stilboestrol, hexoestrol, prednisolone, ephedrine, andrenaline, penicillin, chlorotetracycline, chloramphenicol, tetracycline hydrochloride, oxytetracycline hydrochloride, erythromycin, atropine, thymol, 4-hexylresorcinol, phenolphthalein, aloe-emodin, bis-hydroxycoumarin of the formula: mandelic acid, lactic acid, chaulmoogric acid, nicotinic acid, nicotinamide, phenacetin and acetanilide. The aluminium alkoxide compounds have the probable formula: (X2AlO) (AlOX)p (AlX2) wherein p represents o or a whole number and each X represents a hydroxy group, a residue of a pharmacologically active substance as defined above, or a residue of a substance yielding a hydrolysis-limiting group as defined above, the aluminium compound containing both hydrolysis limiting and pharmacologically active groups. The Provisional Specification refers to alkyl and alkyl-aryl sulphonic acids as substances having pharmacologically activity for use in the above process.ALSO:Polymeric organic aluminium alkoxide compounds are prepared by reacting one or more aluminium alkoxides with water and a pharmacologically active compound containing at least one hydroxy, carboxylic acid, phenolic, imido or keto-enolic group and with at least one compound containing a hydrolysis-limiting group selected from oleic acid, stearic acid, olley alcohol