Procédé de préparation de nouveaux dérivés d'acides alkényloxybenzoïques
The invention comprises compounds of formula wherein X is halogen or haloalkyl (e.g. CF3), R is alkenyl, Y is -NH.CH2.CH2- or -NH.CH2.CH2.CH2-, and -NR1R2 is dialkylamino, or -Y-NR1R2 represents either an N-linked saturated heterocyclic ring containing a second substituted nitrogen atom or an a -di...
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Zusammenfassung: | The invention comprises compounds of formula wherein X is halogen or haloalkyl (e.g. CF3), R is alkenyl, Y is -NH.CH2.CH2- or -NH.CH2.CH2.CH2-, and -NR1R2 is dialkylamino, or -Y-NR1R2 represents either an N-linked saturated heterocyclic ring containing a second substituted nitrogen atom or an a -dialkylamino-cyclohexyl - methylamino group; their acid addition salts; and their preparation by reacting an alkanol and acid p-X-o-OH-PhCOOH to form the ester, reacting this with an alkenyl halide to form the p-X-o-alkenyloxy-benzoate, saponifying this and then obtaining the acid chloride which is finally reacted with an appropriate amine to add the -Y-NR1R2 group. Pharmaceutical compositions useful as cough suppressants comprise the above compounds with carriers. Liquid preparations, pills and suppositories are mentioned. |
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