Procédé de préparation d'un composé stéroïde

The invention comprises 18-nor-pregn-4 - ene - 3,11,20-trione, 18-nor-pregna-3,11,20,-trione, pharmaceutical compositions thereof and processes for the preparation of 18-nor-pregn-4-ene-3,11,20-trione in which 18-nor-pregn-16-ene-3,11,20-trione is catalytically hydrogenated e.g. with palladium, to form 18-nor-pregna-3,11,20-trione, which is then brominated e.g. with free bromine, to form 4#x-bromo-18-nor-pregna-3,11,20-trione, which is dehydrobrominated e.g. with lithium bromide/lithium carbonate in N,N-dimethylformamide, to obtain the desired 18-nor-pregn-4-ene-3,11,20-trione. Said compositions having antilipaemic activity are administered orally, transcutaneously or rectally as tablets, pills, capsules, injectable solutions and suspensions, or suppositories.