Procédé de préparation d'acide amino-4 hydroxy-1 butylidéne-bisphosphonique-1,1 ou de ses sels

A process for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof which comprises: (a) reacting 4-aminobutyric acid with a mixture of phosphorous acid and PCl3 in the presence of methanesulfonic acid; and (b) recovering said 4-amino-1-hydroxybutylidene1,1-bisphosph...

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Bibliographische Detailangaben
Hauptverfasser:	BRENNER GERALD S, KIECZYKOWSKI GERALD R, JOBSON RONALD B, MELILLO DAVID G
Format:	Patent
Sprache:	fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A process for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof which comprises: (a) reacting 4-aminobutyric acid with a mixture of phosphorous acid and PCl3 in the presence of methanesulfonic acid; and (b) recovering said 4-amino-1-hydroxybutylidene1,1-bisphosphonic acid or salts thereof. e