PHENOXY-HYDROXYPROPYLAMINES AND THEIR PREPARATION

Para-substituted phenoxy-hydroxypropylamines having the general formula AND PHARMACEUTICALLY ACCEPTABLE, NON-TOXIC ACID ADDITION SALTS THEREOF, WHEREIN R' is an isopropyl or tertiarybutyl radical; Z is a member selected from the group consisting of -OR'', -SR'', and -NHCOOR&...

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Hauptverfasser: CARLSSON, STIG A.I, ABLAD, BENGT A.H, BRAENDSTROEM, ARNE E, CORRODI, HANS R, CARLSSON, PER A.E, EK, LARS
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creator CARLSSON, STIG A.I
ABLAD, BENGT A.H
BRAENDSTROEM, ARNE E
CORRODI, HANS R
CARLSSON, PER A.E
EK, LARS
description Para-substituted phenoxy-hydroxypropylamines having the general formula AND PHARMACEUTICALLY ACCEPTABLE, NON-TOXIC ACID ADDITION SALTS THEREOF, WHEREIN R' is an isopropyl or tertiarybutyl radical; Z is a member selected from the group consisting of -OR'', -SR'', and -NHCOOR'', R'' being a straight or branched lower alkyl radical having 1 to 3 carbon atoms; and n is 1, 2, or 3, are disclosed as are methods for their preparation. Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the beta -receptors of the heart making them useful in treating heart diseases in animals including humans.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title PHENOXY-HYDROXYPROPYLAMINES AND THEIR PREPARATION
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