PHENOXY-HYDROXYPROPYLAMINES AND THEIR PREPARATION

Para-substituted phenoxy-hydroxypropylamines having the general formula AND PHARMACEUTICALLY ACCEPTABLE, NON-TOXIC ACID ADDITION SALTS THEREOF, WHEREIN R' is an isopropyl or tertiarybutyl radical; Z is a member selected from the group consisting of -OR'', -SR'', and -NHCOOR&...

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Bibliographische Detailangaben
Hauptverfasser:	CARLSSON, STIG A.I, ABLAD, BENGT A.H, BRAENDSTROEM, ARNE E, CORRODI, HANS R, CARLSSON, PER A.E, EK, LARS
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Para-substituted phenoxy-hydroxypropylamines having the general formula AND PHARMACEUTICALLY ACCEPTABLE, NON-TOXIC ACID ADDITION SALTS THEREOF, WHEREIN R' is an isopropyl or tertiarybutyl radical; Z is a member selected from the group consisting of -OR'', -SR'', and -NHCOOR'', R'' being a straight or branched lower alkyl radical having 1 to 3 carbon atoms; and n is 1, 2, or 3, are disclosed as are methods for their preparation. Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the beta -receptors of the heart making them useful in treating heart diseases in animals including humans.