PHENOXYACETIC ACID DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF

1327164 Phenoxyacetic acid derivatives MERCK PATENT GmbH 3 March 1972 [15 March 1971] 9988/72 Heading C2C Novel compounds (I) (including salts and optical isomers thereof) where R1 is H or C 1 to C 10 alkyl, R2 is H, C 1 to C 4 alkyl or halogen and R3 is pyrrolidino, piperidino, 3 - hydroxy - piperidino or -pyrrolidino, isoindolino optionally substituted in the aromatic ring by alkyl and/or alkoxy and/or halogen or by methylenedioxy, 1,2,3,4-tetrahydro-quinolino, 1,2,3,4 - tetrahydro - 4 - quinolyl, 1 - alkyl- 1,2,3,4 - tetrahydro - 4 - quinolyl, 1 - benzimidazolyl, 2 - alkyl - 1 - benzimidazolyl, 1 - pyrryl, 1 - benzotriazolyl, 2 - indanyl or 4-piperidino-phenyl, are made by standard methods especially using phenols (II) (obtained from the corresponding alkyl ethers) and in certain cases R3 can be introduced by cyclization. Pharmaceutical preparations giving rise to cholesterol - level - reducing, triglyceridelevel-reducing and/or enzyme-inducing effects contain (I) as active ingredient. Administration may be parenterally, enterally or topically.