ALKYL 1,1A,2,6B-TETRAHYDROCYCLOPROP(B)INDOLE-1-CARBOXYLATES AND ACIDS

1304232 Tetrahydrocyclopropaindole-1 -carboxylic acids A H ROBINS CO Inc 12 Jan 1971 [26 Jan 1970] 1498/71 Heading C2C Novel compounds I: in which R is XCO- or XNHCO; R1 is H or CH 3 ; R 2 is 1-8C alkyl or alkoxy, CF 3 ; F, Cl or Br; n is 0, 1 or 2 and X is 1-naphthyl, or phenyl, which phenyl radical may optionally be substituted by 1-8C alkyl or alkoxy, CF 3 or halo; and their 1-8C alkyl esters are prepared by reacting compounds II: with a 1-8C alkyl diazoacetate to give the esters of I and separating these into their exo and endo forms and/or hydrolysing the esters to give the free acids. Pharmaceutical compositions comprise a compound I together with a suitable diluent or carrier. The compositions may be administered orally or parenterally as anti-inflammatory agents.