PROCEDE DE PREPARATION DES NOUVEAUX DERIVES DE L'ACIDE THIAZOLYL BENZOIQUE

1308028 m - (2 - Thiazolyl) - benzoic acids SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 14 May 1971 [12 June 1970] 28639/70 Heading C2C Novel m - (2 - thiazolyl) - benzoic acids of the general formula wherein A is a hydrogen or halogen atom or a C 1-5 alkyl or C 1-5 alkoxy group, R is a hydrogen atom, a C 1-5 alkyl group or a phenyl group optionally substituted by one or more halogen atoms and/or one or more C 1-5 alkyl or C 1-5 alkoxy groups and R1 is a hydrogen atom or C 1-5 alkyl group, and, when R1 is a hydrogen atom, addition salts thereof with mineral or organic bases are prepared by treating a m-cyanobenzoic acid of the general formula with hydrogen sulphide and reacting the resulting m-thiocarbamoylbenzoic acid of the general formula with a compound of the general formula RCOCH 2 X, wherein X is a chlorine or bromine atom; followed optionally by salification of a resulting free acid with a mineral or organic base. Pharmaceutical compositions having fibrinolytic, thrombolytic and platelet adhesiveness and aggregation-decreasing activity comprise, as active ingredient, a m-(2-thiazolyl)-benzoic acid of the first general formula above or a physiologically tolerable salt of such a free acid formed with a mineral or organic base, in admixture or conjunction with a pharmaceutically suitable carrier, and may be administered orally, rectally or parenterally.