MODULATION OF GENE TRANSCRIPTION USING ANTISENSE OLIGONUCLEOTIDES TARGETING REGULATORY RNAS

Described herein are methods of modulating gene transcription using antisense oligonucleotides (ASOs) targeting regulatory RNAs, such as promoter-associated RNAs and enhancer RNAs. These methods are useful for modulating the levels of gene products, for example, increasing expression of Carbamoyl-Ph...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	KELKAR, RACHANA S, BUMCROT, DAVID A, SEHGAL, ALFICA, MATTHEWS, BRYAN J, GAMBOA, MARIO ESTEBAN CONTRERAS, LIU, YUTING, ROY, SUBHADEEP, MOUKHEIBER, HENRY MUNIR, GUO, YUCHUN, CARAVELLA, JUSTIN A, PAI, RUTUJA SUDHAKAR, JUNG, YUN JOON
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Described herein are methods of modulating gene transcription using antisense oligonucleotides (ASOs) targeting regulatory RNAs, such as promoter-associated RNAs and enhancer RNAs. These methods are useful for modulating the levels of gene products, for example, increasing expression of Carbamoyl-Phosphatase Synthetase 1 (CPS1), thereby treating diseases associated with aberrant gene expression. L'invention concerne des méthodes de modulation de la transcription génique à l'aide d'oligonucléotides antisens (ASO) ciblant des ARN régulateurs, tels que des ARN associés au promoteur et des ARN amplificateurs. Ces méthodes sont utiles pour moduler les niveaux de produits géniques, par exemple, augmenter l'expression de carbamoyl-phosphatase synthétase 1 (CPS1), ce qui permet de traiter des maladies associées à une expression génique aberrante.