MACROCYCLIC BTK INHIBITORS
The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of BTK (Bruton's Tyrosine Kinase). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as wel...
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| creator | BUIJSMAN, ROGIER CHRISTIAN DE MAN, ADRIANUS PETRUS ANTONIUS VAN CAUTER, FREEK VAN GEMERT, SANDER PETRUS WILHELMUS STERRENBURG, JAN GERARD DE WIT, JOERI JOHANNES PETRUS MULDER, WINFRIED ROBERT GROBBEN, YVONNE SIMONS-VAN RIEL, WILHELMINA ELISABETH MULLER, MICHELLE PRINSEN, MARTINE BERENDINA WILHEMINA VU-PHAM, DIEP VAN MIL, YVONNE GERTRUDA THEODORA HENDRIKA |
| description | The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of BTK (Bruton's Tyrosine Kinase). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicament, in particular for the treatment of Bruton's Tyrosine Kinase (BTK) mediated disorders, such as cancer.
La présente invention concerne des composés macrocycliques et des compositions contenant lesdits composés agissant en tant qu'inhibiteurs de kinase, en particulier en tant qu'inhibiteurs de BTK (tyrosine kinase de Bruton). De plus, la présente invention concerne des procédés de préparation des composés décrits, ainsi que des procédés d'utilisation de ceux-ci, par exemple en tant que médicament, en particulier pour le traitement de troubles médiés par la tyrosine kinase de Bruton (BTK) tels que le cancer. |
| format | Patent |
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La présente invention concerne des composés macrocycliques et des compositions contenant lesdits composés agissant en tant qu'inhibiteurs de kinase, en particulier en tant qu'inhibiteurs de BTK (tyrosine kinase de Bruton). De plus, la présente invention concerne des procédés de préparation des composés décrits, ainsi que des procédés d'utilisation de ceux-ci, par exemple en tant que médicament, en particulier pour le traitement de troubles médiés par la tyrosine kinase de Bruton (BTK) tels que le cancer.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230622&DB=EPODOC&CC=CA&NR=3241069A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230622&DB=EPODOC&CC=CA&NR=3241069A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BUIJSMAN, ROGIER CHRISTIAN</creatorcontrib><creatorcontrib>DE MAN, ADRIANUS PETRUS ANTONIUS</creatorcontrib><creatorcontrib>VAN CAUTER, FREEK</creatorcontrib><creatorcontrib>VAN GEMERT, SANDER PETRUS WILHELMUS</creatorcontrib><creatorcontrib>STERRENBURG, JAN GERARD</creatorcontrib><creatorcontrib>DE WIT, JOERI JOHANNES PETRUS</creatorcontrib><creatorcontrib>MULDER, WINFRIED ROBERT</creatorcontrib><creatorcontrib>GROBBEN, YVONNE</creatorcontrib><creatorcontrib>SIMONS-VAN RIEL, WILHELMINA ELISABETH</creatorcontrib><creatorcontrib>MULLER, MICHELLE</creatorcontrib><creatorcontrib>PRINSEN, MARTINE BERENDINA WILHEMINA</creatorcontrib><creatorcontrib>VU-PHAM, DIEP</creatorcontrib><creatorcontrib>VAN MIL, YVONNE GERTRUDA THEODORA HENDRIKA</creatorcontrib><title>MACROCYCLIC BTK INHIBITORS</title><description>The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of BTK (Bruton's Tyrosine Kinase). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicament, in particular for the treatment of Bruton's Tyrosine Kinase (BTK) mediated disorders, such as cancer.
La présente invention concerne des composés macrocycliques et des compositions contenant lesdits composés agissant en tant qu'inhibiteurs de kinase, en particulier en tant qu'inhibiteurs de BTK (tyrosine kinase de Bruton). De plus, la présente invention concerne des procédés de préparation des composés décrits, ainsi que des procédés d'utilisation de ceux-ci, par exemple en tant que médicament, en particulier pour le traitement de troubles médiés par la tyrosine kinase de Bruton (BTK) tels que le cancer.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJDydXQO8neOdPbxdFZwCvFW8PTz8HTyDPEPCuZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfHOjsZGJoYGZpaOhsZEKAEA83Ifvg</recordid><startdate>20230622</startdate><enddate>20230622</enddate><creator>BUIJSMAN, ROGIER CHRISTIAN</creator><creator>DE MAN, ADRIANUS PETRUS ANTONIUS</creator><creator>VAN CAUTER, FREEK</creator><creator>VAN GEMERT, SANDER PETRUS WILHELMUS</creator><creator>STERRENBURG, JAN GERARD</creator><creator>DE WIT, JOERI JOHANNES PETRUS</creator><creator>MULDER, WINFRIED ROBERT</creator><creator>GROBBEN, YVONNE</creator><creator>SIMONS-VAN RIEL, WILHELMINA ELISABETH</creator><creator>MULLER, MICHELLE</creator><creator>PRINSEN, MARTINE BERENDINA WILHEMINA</creator><creator>VU-PHAM, DIEP</creator><creator>VAN MIL, YVONNE GERTRUDA THEODORA HENDRIKA</creator><scope>EVB</scope></search><sort><creationdate>20230622</creationdate><title>MACROCYCLIC BTK INHIBITORS</title><author>BUIJSMAN, ROGIER CHRISTIAN ; DE MAN, ADRIANUS PETRUS ANTONIUS ; VAN CAUTER, FREEK ; VAN GEMERT, SANDER PETRUS WILHELMUS ; STERRENBURG, JAN GERARD ; DE WIT, JOERI JOHANNES PETRUS ; MULDER, WINFRIED ROBERT ; GROBBEN, YVONNE ; SIMONS-VAN RIEL, WILHELMINA ELISABETH ; MULLER, MICHELLE ; PRINSEN, MARTINE BERENDINA WILHEMINA ; VU-PHAM, DIEP ; VAN MIL, YVONNE GERTRUDA THEODORA HENDRIKA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3241069A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>BUIJSMAN, ROGIER CHRISTIAN</creatorcontrib><creatorcontrib>DE MAN, ADRIANUS PETRUS ANTONIUS</creatorcontrib><creatorcontrib>VAN CAUTER, FREEK</creatorcontrib><creatorcontrib>VAN GEMERT, SANDER PETRUS WILHELMUS</creatorcontrib><creatorcontrib>STERRENBURG, JAN GERARD</creatorcontrib><creatorcontrib>DE WIT, JOERI JOHANNES PETRUS</creatorcontrib><creatorcontrib>MULDER, WINFRIED ROBERT</creatorcontrib><creatorcontrib>GROBBEN, YVONNE</creatorcontrib><creatorcontrib>SIMONS-VAN RIEL, WILHELMINA ELISABETH</creatorcontrib><creatorcontrib>MULLER, MICHELLE</creatorcontrib><creatorcontrib>PRINSEN, MARTINE BERENDINA WILHEMINA</creatorcontrib><creatorcontrib>VU-PHAM, DIEP</creatorcontrib><creatorcontrib>VAN MIL, YVONNE GERTRUDA THEODORA HENDRIKA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BUIJSMAN, ROGIER CHRISTIAN</au><au>DE MAN, ADRIANUS PETRUS ANTONIUS</au><au>VAN CAUTER, FREEK</au><au>VAN GEMERT, SANDER PETRUS WILHELMUS</au><au>STERRENBURG, JAN GERARD</au><au>DE WIT, JOERI JOHANNES PETRUS</au><au>MULDER, WINFRIED ROBERT</au><au>GROBBEN, YVONNE</au><au>SIMONS-VAN RIEL, WILHELMINA ELISABETH</au><au>MULLER, MICHELLE</au><au>PRINSEN, MARTINE BERENDINA WILHEMINA</au><au>VU-PHAM, DIEP</au><au>VAN MIL, YVONNE GERTRUDA THEODORA HENDRIKA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MACROCYCLIC BTK INHIBITORS</title><date>2023-06-22</date><risdate>2023</risdate><abstract>The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of BTK (Bruton's Tyrosine Kinase). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicament, in particular for the treatment of Bruton's Tyrosine Kinase (BTK) mediated disorders, such as cancer.
La présente invention concerne des composés macrocycliques et des compositions contenant lesdits composés agissant en tant qu'inhibiteurs de kinase, en particulier en tant qu'inhibiteurs de BTK (tyrosine kinase de Bruton). De plus, la présente invention concerne des procédés de préparation des composés décrits, ainsi que des procédés d'utilisation de ceux-ci, par exemple en tant que médicament, en particulier pour le traitement de troubles médiés par la tyrosine kinase de Bruton (BTK) tels que le cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | MACROCYCLIC BTK INHIBITORS |
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