MACROCYCLIC BTK INHIBITORS

The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of BTK (Bruton's Tyrosine Kinase). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as wel...

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Hauptverfasser:	BUIJSMAN, ROGIER CHRISTIAN, DE MAN, ADRIANUS PETRUS ANTONIUS, VAN CAUTER, FREEK, VAN GEMERT, SANDER PETRUS WILHELMUS, STERRENBURG, JAN GERARD, DE WIT, JOERI JOHANNES PETRUS, MULDER, WINFRIED ROBERT, GROBBEN, YVONNE, SIMONS-VAN RIEL, WILHELMINA ELISABETH, MULLER, MICHELLE, PRINSEN, MARTINE BERENDINA WILHEMINA, VU-PHAM, DIEP, VAN MIL, YVONNE GERTRUDA THEODORA HENDRIKA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of BTK (Bruton's Tyrosine Kinase). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicament, in particular for the treatment of Bruton's Tyrosine Kinase (BTK) mediated disorders, such as cancer. La présente invention concerne des composés macrocycliques et des compositions contenant lesdits composés agissant en tant qu'inhibiteurs de kinase, en particulier en tant qu'inhibiteurs de BTK (tyrosine kinase de Bruton). De plus, la présente invention concerne des procédés de préparation des composés décrits, ainsi que des procédés d'utilisation de ceux-ci, par exemple en tant que médicament, en particulier pour le traitement de troubles médiés par la tyrosine kinase de Bruton (BTK) tels que le cancer.