SINGLE DOMAIN ANTIBODIES FOR PREVENTION OF CLOSTRIDIUM DIFFICILE INFECTION

The present disclosure relates to single domain antibodies which binds to Clostridium difficile toxin B and their use in the treatment and prevention of Clostridium difficile infection. Further disclosed are nucleic acids and vectors encoding the single domain antibodies, host cells for expression o...

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Bibliographische Detailangaben
Hauptverfasser:	RODRIGUEZ-RODRIGUEZ, EVERARDO, LAUSTSEN, ANDREAS HOUGAARD, LAUSTSEN, MADS AAGE, THRANE, SANDRA WINGAARD
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The present disclosure relates to single domain antibodies which binds to Clostridium difficile toxin B and their use in the treatment and prevention of Clostridium difficile infection. Further disclosed are nucleic acids and vectors encoding the single domain antibodies, host cells for expression of the single domain antibodies, methods of manufacture and compositions. La présente invention concerne des anticorps à domaine unique qui se lient à la toxine B du Clostridium difficile et leur utilisation dans le traitement et la prévention d'une infection à Clostridium difficile. L'invention concerne en outre des acides nucléiques et des vecteurs codant pour les anticorps à domaine unique, des cellules hôtes pour l'expression des anticorps à domaine unique, des procédés de fabrication et des compositions.