CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF PYRIMIDINE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT 2A SEROTONIN RECEPTOR

CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF PYRIMIDINE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT 2A SEROTONIN RECEPTOR

The present disclosure relates to a crystalline form and crystalline salts of s of N-(3-(4,6-dimethylpyrimidin-5-yl)-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)cyclopropanecarboxamide (Compound Ia) and pharmaceutical compositions thereof that modulate the activity of the 5HT2A 5 receptor. The present discl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BLACKBURN, ANTHONY C, LIN, JUIN
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure relates to a crystalline form and crystalline salts of s of N-(3-(4,6-dimethylpyrimidin-5-yl)-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)cyclopropanecarboxamide (Compound Ia) and pharmaceutical compositions thereof that modulate the activity of the 5HT2A 5 receptor. The present disclosure further relates to processes useful in the preparation of crystalline form and salts of Compound Ia and pharmaceutical compositions thereof. La présente divulgation concerne une forme cristalline et des sels cristallins de N-(3-(4,6-diméthylpyrimidin-5-yl)-4-(2-(pyrrolidin-1-yl)éthoxy)phényl)cyclopropanecarboxamide (composé Ia) et des compositions pharmaceutiques de celui-ci qui modulent l'activité du récepteur 5 HT2A. La présente divulgation concerne en outre des processus utiles dans la préparation de la forme cristalline et des sels du composé Ia et des compositions pharmaceutiques de celui-ci.