EGFRVIII-TARGETED COMPOUNDS AND USES THEREOF

Compounds, e.g., radioimmunoconjuguates including a chelating moiety or a metal complex thereof, a linker, and an EGFRvIII targeting moiety. Pharmaceutical compositions of such compounds and methods of treatment for conditions, e.g., cancer, using such pharmaceutical compositions. L'invention c...

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Bibliographische Detailangaben
Hauptverfasser:	TURNBULL, WILLIAM LESLIE, JARAMILLO, MARIA, WU, CUNLE, DUFFY, IAN R, MARCIL, ANNE, METCALF, JULIE, GRINSHTEIN, NATALIE, SULEA, TRAIAN, MORENO, MARIA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds, e.g., radioimmunoconjuguates including a chelating moiety or a metal complex thereof, a linker, and an EGFRvIII targeting moiety. Pharmaceutical compositions of such compounds and methods of treatment for conditions, e.g., cancer, using such pharmaceutical compositions. L'invention concerne des composés, par exemple des radio-immunoconjugués comprenant une fraction chélatante ou un complexe métallique de celle-ci, un lieur et une fraction de ciblage de EGFRvIII. L'invention concerne également des compositions pharmaceutiques de ces composés et des méthodes de traitement d'affections, par exemple le cancer, à l'aide de telles compositions pharmaceutiques.