EXPANSION PROCESSES AND AGENTS FOR TUMOR INFILTRATING LYMPHOCYTES

The present invention provides a method of treating a cancer in a patient or subject in need thereof comprising administering a population of modified tumor infiltrating lymphocytes (TILs), wherein the population of TILs has been modified by adding an epigenetic reprogramming agent to the cell cultu...

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Bibliographische Detailangaben
Hauptverfasser:	MACHIN, MARCUS, YUHAS, ANDREW, CUBAS, RAFAEL, ZHANG, YONGLIANG
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a method of treating a cancer in a patient or subject in need thereof comprising administering a population of modified tumor infiltrating lymphocytes (TILs), wherein the population of TILs has been modified by adding an epigenetic reprogramming agent to the cell culture medium used for expanding the TILs. La présente invention concerne une méthode de traitement d'un cancer chez un patient ou un sujet dont l'état le nécessite, comprenant l'administration d'une population de lymphocytes infiltrant la tumeur (TIL) modifiés, la population de TIL ayant été modifiée par l'ajout d'un agent de reprogrammation épigénétique au milieu de culture cellulaire utilisé pour l'expansion des TIL.