NOVEL BENZOFURANYL HYDROXYPHENYL METHANONE DERIVATIVE COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

The present invention provides a benzofuranyl hydroxyphenyl methanone derivative compound having a specific chemical structure, a HSP47-inhibitory pharmaceutical compound comprising a pharmaceutically acceptable salt thereof, and a preparation method therefor. The benzofuranyl hydroxyphenyl methanon...

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Bibliographische Detailangaben
Hauptverfasser:	LIM, DONG CHUL, CHOI, SEI HYUN, PARK, JUNG GYU
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides a benzofuranyl hydroxyphenyl methanone derivative compound having a specific chemical structure, a HSP47-inhibitory pharmaceutical compound comprising a pharmaceutically acceptable salt thereof, and a preparation method therefor. The benzofuranyl hydroxyphenyl methanone derivative compound included in the HSP47-inhibitory pharmaceutical compound of the present invention can be effectively used, in the medical and pharmaceutical fields, for HSP47 inhibition such as that in the prevention or treatment of fibrosis, inflammatory diseases and cancer. La présente invention concerne un composé dérivé de benzofuranyl-hydroxyphényl-méthanone ayant une structure chimique spécifique, un composé pharmaceutique inhibiteur de HSP47 comprenant un sel pharmaceutiquement acceptable associé, et son procédé de préparation. Le composé dérivé de benzofuranyl-hydroxyphényl-méthanone inclus dans le composé pharmaceutique inhibiteur de HSP47 selon la présente invention peut être utilisé efficacement, dans les domaines médical et pharmaceutique, pour inhiber HSP47 comme dans la prévention ou le traitement de la fibrose, de maladies inflammatoires et du cancer.