FUSED HETEROCYCLIC RINGS AS RIPK1 INHIBITORS

The invention provides novel substituted heterocyclic rings represented by Formula I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of RIPK1 and the therape...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	KANG, HONGJUN, YOON, CHEOLHWAN, PARK, KITAE, JEONG, HEEJIN, CHOI, SUNGMIN, YANG, INHO, KIM, MINHA, SEO, JEONGBEOB, KIM, JINYOUNG, JEON, SEEUN, KIM, SUNJOO, KIM, NAMHEE, MIN, JIAE, HAN, CHEOLKYU, HAN, SANGBAE, KWON, YOUNGEUN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides novel substituted heterocyclic rings represented by Formula I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of RIPK1 and the therapeutic methods. L'invention concerne de nouveaux hétérocycles substitués représentés par la formule I, ou un sel, un solvate, un polymorphe, un ester, un tautomère ou un promédicament pharmaceutiquement acceptable de ceux-ci, et une composition comprenant ces composés. Les composés selon l'invention peuvent être utilisés comme inhibiteurs de RIPK1, notamment dans des méthodes thérapeutiques associées.