SYNTHETIC CHROMOSOME ENCODING TWO OR MORE CHIMERIC ANTIGEN RECEPTORS BINDING TO TUMOR ASSOCIATED ANTIGENS

Aspects of the present invention relate to synthetic chromosomes that may be incorporated into leukocytes, wherein the synthetic chromosomes comprise nucleic acid sequences encoding multiple Chimeric Antigen Receptors (CARs). Such manipulated leukocytes can be used in medicine, notably in the treatm...

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Bibliographische Detailangaben
Hauptverfasser:	GREENE, AMY L, LYBERG, KATARINA, REMNESTAL, JULIA, PERKINS, EDWARD L, BROCCOLI, DOMINIQUE, MANNE, KARA PASCARELLI, WINQVIST, OLA, ANDERSSON, JOHN, EKOFF, MARIA, KESZEI, MARTON
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Aspects of the present invention relate to synthetic chromosomes that may be incorporated into leukocytes, wherein the synthetic chromosomes comprise nucleic acid sequences encoding multiple Chimeric Antigen Receptors (CARs). Such manipulated leukocytes can be used in medicine, notably in the treatment of a cancer such as in the treatment of cancer having solid tumors. The leukocytes may be lymphocytes, including tumor-infiltrating lymphocytes, T cells, NK cells or B cells. In a preferred aspect, the leucocytes are syngeneic and T cells. Des aspects de la présente invention concernent des chromosomes synthétiques qui peuvent être incorporés dans des leucocytes, les chromosomes synthétiques comprenant des séquences d'acides nucléiques codant pour de multiples récepteurs antigéniques chimériques (CAR). De tels leucocytes manipulés peuvent être utilisés en médecine, notamment dans le traitement d'un cancer tel que dans le traitement du cancer ayant des tumeurs solides. Les leucocytes peuvent être des lymphocytes, y compris des lymphocytes infiltrant les tumeurs, des lymphocytes T, des cellules NK ou des cellules B. Dans un aspect préféré, les leucocytes sont des cellules syngéniques et des lymphocytes T.