METHOD FOR QUANTIFICATION OF A LEVEL OF RESPONSE TO HYPOGLOSSAL NERVE STIMULATION AND METHOD OF PREDICTING

Disclosed herein is a Computer-implemented method for quantification of a level of response to nerve stimulation, the method comprising the following steps:a) transfer a stimulation parameter data to a data processing unit;b) transfer at least a subgroup of physiological data corresponding to a subject to the data processing unit;c) identify at least one physiological signal of the physiological data corresponding to the therapy's impact on the subject's airway opening;d) detect ON-instants and OFF-instants in a defined time segment of the physiological data, wherein each ON-instant corresponds to an instant of time in which the subject was stimulated and wherein each OFF-instant corresponds to an instant of time in which the subject was not stimulated;e) detect at least one breath cycle;f) for each breath cycle detected, analyze an airflow segment and check if it was synchronized with an ON-instant or with an OFF-instant;g) sort each airflow segment into one of two groups based on its respectively checked synchronization with an ON/OFF-instant, the two groups being an ON-group comprising airflow signals that are synchronized with ON-instants and an OFF-group comprising airflow signals that are synchronized with OFF-instants;h) for each of the two groups, separately determine an airflow curve from all airflow segments of each respective group;i) calculate an volume of air for each of the two airflows;j) determine an impact of stimulation based on visualization of the two airflows and/or on a ratio of the two volumes.