HOST DIRECTED DRUG COMBINATIONS FOR TREATMENT OF VIRAL INFECTIONS

Drug combinations, compositions including pharmaceutical compositions as well as methods of using and treating a viral infection, including one of the following: (1) atovaquone with a second group of substances consisting of ademetionine, albendazole, celastrol, cepharantine, chloroquine, cycloheximide, diethylstilbestrol, gemcitabine, homoharringtonine, hydroxy progesterone, imatinib, imipramine, indomethacin, ivermectin, niclosamide, raloxifene, sorafenib, and tipifarnib; or (2) cepharantine with a second group of substances consisting of ademetionine, albendazole, atovaquone, celastrol, chloroquine, cycloheximide, diethylstilbestrol, gemcitabine, homoharringtonine, hydroxy progesterone, imatinib, imipramine, indomethacin, ivermectin, raloxifene, sorafenib, and tipifarnib; or (3) one substance selected from a first group of substances consisting of ademetionine, albendazole, atovaquone, celastrol, cepharantine, chloroquine, cycloheximide, diethylstilbestrol, gemcitabine, homoharringtonine, hydroxy progesterone, imatinib, imipramine, indomethacin, ivermectin, raloxifene, sorafenib, tipifarnib in combination with a second group of substances selected from the group consisting of ademetionine, albendazole, celastrol, cepharantine, chloroquine, cycloheximide, diethylstilbestrol, gemcitabine, homoharringtonine, hydroxy progesterone, imatinib, imipramine, indomethacin, ivermectin, raloxifene, sorafenib, and tipifarnib. L'invention concerne des combinaisons et des compositions de médicaments comprenant des compositions pharmaceutiques ainsi que des méthodes d'utilisation et de traitement d'une infection virale, comprenant l'un des éléments suivants : (1) l?atovaquone avec un second groupe de substances constitué par l?adémétionine, l?albendazole, le célastrol, la cépharantine, la chloroquine, le cycloheximide, le diéthylstilbestrol, la gemcitabine, la homoharringtonine, l?hydroxy progestérone, l?imatinib, l?imipramine, l?indométacine, l?ivermectine, le niclosamide, le raloxifène, le sorafénib et le tipifarnib ; ou (2) la cépharantine avec un second groupe de substances constitué par l'adémétionine, l?albendazole, l?atovaquone, le célastrol, la chloroquine, le cycloheximide, le diéthylstilbestrol, la gemcitabine, l?homoharringtonine, l?hydroxy progestérone, l?imatinib, l?imipramine, l?indométacine, l?ivermectine, le raloxifène, le sorafénib et le tipifarnib ; ou (3) une substance choisie parmi un premier groupe de substances constitué par l?adémétionine, l?alben