(R)-N-ETHYL-5-FLUORO-N-ISOPROPYL-2-((5-(2-(6-((2-METHOXYETHYL)(METHYL)AMINO)-2-METHYLHEXAN-3-YL)-2,6-DIAZASPIRO[3.4]OCTAN-6-YL)-1,2,4-TRIAZIN-6-YL)OXY)BENZAMIDE BESYLATE SALT FOR THE TREATMENT OF DISEASES SUCH AS CANCE

(R)-N-ETHYL-5-FLUORO-N-ISOPROPYL-2-((5-(2-(6-((2-METHOXYETHYL)(METHYL)AMINO)-2-METHYLHEXAN-3-YL)-2,6-DIAZASPIRO[3.4]OCTAN-6-YL)-1,2,4-TRIAZIN-6-YL)OXY)BENZAMIDE BESYLATE SALT FOR THE TREATMENT OF DISEASES SUCH AS CANCE

The present invention relates to (R) -N-ethyl-5-fluoro-N-isopropyl-2- ( (5- (2- (6- ( (2-methoxyethyl) (methyl) amino) -2-methylhexan-3-yl) -2, 6-diazaspiro [3.4] octan-6-yl) -1, 2, 4-triazin-6-yl) oxy) benzamide besylate salt and solvates thereof. This compound may be useful for therapy and/or prop...

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Bibliographische Detailangaben
Hauptverfasser: CLEATOR, EDWARD, SMOLDERS, SIMON JAN C, BEN HAIM, CYRIL, GEERTMAN, ROBERT MICHAEL, LIU, YINGTAO, NG, ALICIA TEE FUAY, QUEROLLE, OLIVIER ALEXIS GEORGES, AHUJA, DIPALI, THURING, JOHANNES WILHELMUS J, CAI, WEI, DARVILLE, NICOLAS FREDDY JACQUES BRUNO, PANDE, VINEET, DAI, XUEDONG
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The present invention relates to (R) -N-ethyl-5-fluoro-N-isopropyl-2- ( (5- (2- (6- ( (2-methoxyethyl) (methyl) amino) -2-methylhexan-3-yl) -2, 6-diazaspiro [3.4] octan-6-yl) -1, 2, 4-triazin-6-yl) oxy) benzamide besylate salt and solvates thereof. This compound may be useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compound, and use as menin/MLL protein/protein interaction inhibitor, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes. La présente invention concerne un bésylate de (R) -N-éthyl-5-fluoro-N-isopropyl-2- ( (5- (2- (6- ( (2-méthoxyéthyl) (méthyl) amino) -2-méthylhexan-3-yl) -2, 6-diazaspiro [3.4] octan-6-yl) -1, 2, 4-triazin-6-yl) oxy) benzamide et des solvates de celui-ci. Ce composé peut être utile pour la thérapie et/ou la prophylaxie chez un mammifère, une composition pharmaceutique comprenant un tel composé, et son utilisation en tant qu'inhibiteur de l'interaction ménine/protéine MLL/protéine, utile pour le traitement de maladies telles que le cancer, notamment mais non exclusivement la leucémie, le syndrome myélodysplasique (MDS) et des néoplasmes myéloprolifératifs (MPN); et le diabète.