HUMAN FIBROBLAST GROWTH FACTOR 1 (FGF-1) MUTEINS, THEIR DIMERS AND USES

HUMAN FIBROBLAST GROWTH FACTOR 1 (FGF-1) MUTEINS, THEIR DIMERS AND USES

The present invention relates to human fibroblast growth factor (FGF-1) muteins having decreased mitogenicity, dimers of human FGF-1 muteins, as well as such human FGF-1 muteins and dimers of such muteins for use in reducing blood glucose level, particularly for use in the treatment of diabetes. La...

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Hauptverfasser: PIECZYKOLAN, JERZY SZCZEPAN, ZAKRZEWSKA, MA?GORZATA URSZULA, DRZAZGA, EWA, OTLEWSKI, JACEK JOZEF, BAZYD?O-GUZENDA, KATARZYNA, WIECZOREK, MACIEJ, JANISZEWSKI, MICHA? MIECZYS?AW, KROWARSCH, DANIEL RAFA?, CZYREK, ALEKSANDRA ANNA, BUDA, PAWE?
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:The present invention relates to human fibroblast growth factor (FGF-1) muteins having decreased mitogenicity, dimers of human FGF-1 muteins, as well as such human FGF-1 muteins and dimers of such muteins for use in reducing blood glucose level, particularly for use in the treatment of diabetes. La présente invention concerne des mutéines du facteur de croissance des fibroblastes 1 (FGF-1) humain ayant une mitogénicité réduite, des dimères de mutéines du FGF-1 humain, ainsi que des utilisations de ces mutéines du FGF-1 humain et de ces dimères de telles mutéines pour réduire la glycémie, en particulier dans le traitement du diabète.