ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF CANCER

ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF CANCER

The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3?kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): (I) or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6...

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Bibliographische Detailangaben
Hauptverfasser: HICKEY, EUGENE R, ANDERSON, ERIN DANIELLE, ARONOW, SEAN DOUGLAS, BOYLES, NICHOLAS A, IRVIN, THOMAS COMBS, LONG, KATELYN FRANCES, WELCH, MICHAEL BRIAN, CHEN, XIAOHONG, KNIGHT, JENNIFER LYNN, MAYNE, CHRISTOPHER GLENN, DAWADI, SURENDRA, POTOTSCHNIG, GERIT MARIA, MCLEAN, JOHNATHAN ALEXANDER, KESICKI, EDWARD A, WIDJAJA, TIEN, KOLAKOWSKI, GABRIELLE R, KUMAR, MANOJ, WANG, HUA-YU
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3?kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): (I) or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof. L'invention concerne des composés de formule (I) en tant qu'inhibiteurs chroménone allostériques de la phosphoinositide 3-kinase (PI3K) utiles dans le traitement de maladies ou de troubles associés à la modulation de PI3K, Formule (I) : (I) ou des sels pharmaceutiquement acceptables de ceux-ci, où R, R1, R2, R3, R4, R5, R6, R7, et R8 sont tels que définis dans la description. L'invention concerne également des procédés de fabrication et d'utilisation des composés de formule (I) ou des sels pharmaceutiquement acceptables de ceux-ci.