EXATECAN DERIVATIVES AND ANTIBODY-DRUG CONJUGATES THEREOF

Disclosed herein, in part, are compounds (I) which are exatecan derivatives with novel chemical linkers that include cathepsin B cleavable moieties, and conjugated to targeting antibodies. L'invention concerne, en partie, des composés (I) qui sont des dérivés d'exatecan avec de nouveaux li...

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Hauptverfasser:	STROP, PETER, WONG, JANICA CHEUK-YING, PONS, JAUME, VRLJIC, MARIJA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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